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KMID : 0378019670100060131
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New Medical Journal
1967 Volume.10 No. 6 p.131 ~ p.137
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Two Cases of Acute Hemolytic Anemia Induced Probably by Secobarbital
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嚴柱鉉/Um, Joo Hyun
金鍾聲/兪台沂/李柱炅/Kim, Jong-Seung/Yiu, Tai-Gi/Lee, Joo-Kyung
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Abstract
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One 19-year-old male was admitted to P.N.U. Hospital on March 19, 1966, because of severe recurrent, colicky abdominal pain, chillness, nausea, vomitting, headache, sweating, extreme weakness and dizziness for two days´duration, and brownish dark urine on one occation after 24 hours of administration of the Secobarbital 400mg (4 cap.).
Another 21-year-old male was admitted to this hospital, on March 21,. 1966, because of unconsciousness after ingestion of the secobarbital 1, 700mg (17 cap.).. After recovery from this state on the second days of admission, he has complained the . chillness, diffuse, colicky abdominal pain, myalgia, and headache, and also discharged dark urine in the evening.
The diagnosis of the acute hemolytic anemia was established by means of the abovesymtoms, physical examinations and laboratory findings of which, the peripheral blood showed hemoglobinemia in the serum, increased bilirubin titer, mostly indirect, and spherocytosis; hemoglobin in the urine.
After initial. response to therapy with blood transfusion (5 Pt.), and to control of fluid and electrolytes, the clinical and laboratory findings were much improved within the two week´s of admission. The prednisolone has been administered 80 mg a day at first on the 3rd days of admission,- and then decreased the dose until 20 mg once a day for all the 5 days.
Both the patients were discharged on the 14th day of admission and all have good condition until one year after then.
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